Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins

被引：22

作者：

Hartley, JA

Hazrati, A

Hodgkinson, TJ

Kelland, LR

Khanim, R

Shipman, M

Suzenet, F

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

[2] UCL, Royal Free & Univ Coll Med Sch, Dept Oncol, CRC Drug DNA Interact Res Grp, London W1P 8BT, England

[3] Inst Canc Res, CRC Ctr Canc Therapeut, Surrey SM2 2NG, England

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 23期

关键词：

D O I：

10.1039/b006723g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of dimeric compounds 1a-c designed around the epoxide domain of the azinomycins have been synthesised and demonstrated to be highly efficient DNA interstrand cross-linking agents.

引用

页码：2325 / 2326

页数：2

共 19 条

[1] NOVEL INTERSTRAND CROSS-LINKS INDUCED BY THE ANTITUMOR ANTIBIOTIC CARZINOPHILIN AZINOMYCIN-B [J].

ARMSTRONG, RW ;

SALVATI, ME ;

NGUYEN, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (08) :3144-3145

[2] Asymmetric synthesis of the left hand portion of the azinomycins [J].

Bryant, HJ ;

Dardonville, CY ;

Hodgkinson, TJ ;

Hursthouse, MB ;

Malik, KMA ;

Shipman, M .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (07) :1249-1255

[3]

CARMICHAEL J, 1987, CANCER RES, V47, P936

[4]

Coleman RS, 1998, SYNLETT, P1031

[5] The United Kingdom Chemical Database Service [J].

Fletcher, DA ;

McMeeking, RF ;

Parkin, D .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1996, 36 (04) :746-749

[6] Highly efficient DNA interstrand crosslinking induced by an antitumor antibiotic, carzinophilin [J].

Fujiwara, T ;

Saito, I ;

Sugiyama, H .

TETRAHEDRON LETTERS, 1999, 40 (02) :315-318

[7]

GATES KS, 1999, 368ORGN AM CHEM SOC, V218

[8]

Hartley JA, 2000, ANGEW CHEM INT EDIT, V39, P3467

[9] AN AGAROSE-GEL METHOD FOR THE DETERMINATION OF DNA INTERSTRAND CROSS-LINKING APPLICABLE TO THE MEASUREMENT OF THE RATE OF TOTAL AND 2ND-ARM CROSS-LINK REACTIONS [J].

HARTLEY, JA ;

BERARDINI, MD ;

SOUHAMI, RL .

ANALYTICAL BIOCHEMISTRY, 1991, 193 (01) :131-134

[10] SYNTHESIS, CHEMICAL-PROPERTY, AND CYTOTOXICITY OF THE CARZINOPHILIN CONGENERS CARRYING A 2-(1-ACYLAMINO-1-ALKOXYCARBONYL)METHYLIDENE-1-AZABICYCLO[3.1.0]HEXANE SYSTEM [J].

HASHIMOTO, M ;

MATSUMOTO, M ;

YAMADA, K ;

TERASHIMA, S .

TETRAHEDRON LETTERS, 1994, 35 (14) :2207-2210

← 1 2 →