Cellular and molecular facets of keratinocyte reepithelization during wound healing

被引：296

作者：

Santoro, MM ^{[1
]}

Gaudino, G ^{[1
]}

机构：

[1] Univ Piemonte Orientale, Dept Med Sci, I-28100 Novara, Italy

来源：

EXPERIMENTAL CELL RESEARCH | 2005年 / 304卷 / 01期

关键词：

keratinocyte; wound healing; reepithelization;

D O I：

10.1016/j.yexcr.2004.10.033

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cutaneous wound healing is a highly coordinated physiological process that rapidly and efficiently restores skin integrity. Reepithelization is a crucial step during wound healing, which involves migration and proliferation of keratinocytes to cover the denuded dermal surface. Recent advances in wound biology clarified the molecular pathways governing keratinocyte reepithelization at wound sites. These new findings point towards novel therapeutic targets and provide suitable methods to promote faster tissue regeneration in vivo. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：274 / 286

页数：13

共 146 条

[11] Functions of hyaluronan in wound repair [J].

Chen, WYJ ;

Abatangelo, G .

WOUND REPAIR AND REGENERATION, 1999, 7 (02) :79-89

[12]

CLARK RAF, 1996, MOL CELL BIOL WOUND

[13]

Colognato H, 2000, DEV DYNAM, V218, P213, DOI 10.1002/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO

[14]

2-R

[15] Hepatocyte growth factor and macrophage-stimulating protein are upregulated during excisional wound repair in rats [J].

Cowin, AJ ;

Kallincos, N ;

Hatzirodos, N ;

Robertson, JG ;

Pickering, KJ ;

Couper, J ;

Belford, DA .

CELL AND TISSUE RESEARCH, 2001, 306 (02) :239-250

[16] Endogenous production of heparin-binding EGF-like growth factor during murine partial-thickness burn wound healing [J].

Cribbs, RK ;

Harding, PA ;

Luquette, MH ;

Besner, GE .

JOURNAL OF BURN CARE & REHABILITATION, 2002, 23 (02) :116-125

[17] Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells [J].

Danilkovitch, A ;

Donley, S ;

Skeel, A ;

Leonard, EJ .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (06) :2218-2227

[18] Oncogenic Signaling Pathways Activated by RON Receptor Tyrosine Kinase [J].

Danilkovitch-Miagkova, Alla .

CURRENT CANCER DRUG TARGETS, 2003, 3 (01) :31-40

[19] Tyrosine phosphorylation of the β4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes [J].

Dans, M ;

Gagnoux-Palacios, L ;

Blaikie, P ;

Klein, S ;

Mariotti, A ;

Giancotti, FG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (02) :1494-1502

[20] Corrective transduction of human epidermal stem cells in laminin-5-dependent junctional epidermolysis bullosa [J].

Dellambra, E ;

Vailly, J ;

Pellegrini, G ;

Bondanza, S ;

Golisano, O ;

Macchia, C ;

Zambruno, G ;

Meneguzzi, G ;

De Luca, M .

HUMAN GENE THERAPY, 1998, 9 (09) :1359-1370

← 1 2 3 4 5 6 7 8 9 10 →