Structure and mechanics of integrin-based cell adhesion

被引：365

作者：

Arnaout, M. Amin

Goodman, Simon L.

Xiong, Jian-Ping

机构：

[1] Massachusetts Gen Hosp, Div Nephrol, Leukocyte Biol & Inflammat Program, Struct Biol Program, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[3] Merck Serono KGaA, Therapeut Area Oncol, D-64271 Darmstadt, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2007年 / 19卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2007.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Integrins are alpha/beta heterodimeric adhesion glycoprotein receptors that regulate a wide variety of dynamic cellular processes such as cell migration, phagocytosis, and growth and development. X-ray crystallography of the integrin ectodomain revealed its modular architecture and defined its metal-dependent interaction with extracellular ligands. This interaction is regulated from inside the cell (inside-out activation), through the short cytoplasmic alpha and beta integrin tails, which also mediate biochemical and mechanical signals transmitted to the cytoskeleton by the ligand-occupied integrins, effecting major changes in cell shape, behavior, and fate. Recent advances in the structural elucidation of integrins and integrin-binding cytoskeleton proteins are the subjects of this review.

引用

页码：495 / 507

页数：13

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