The RFX complex is crucial for the constitutive and CIITA-mediated transactivation of MHC class I and β2-microglobulin genes

被引：99

作者：

Gobin, SJP

Peijnenburg, A

van Eggermond, M

van Zutphen, N

van den Berg, R

van den Elsen, PJ ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Immunohematol, NL-2333 ZA Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Blood Bank, NL-2333 ZA Leiden, Netherlands

来源：

IMMUNITY | 1998年 / 9卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(00)80636-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In type III bare lymphocyte syndrome (BLS) patients, defects in the RFX protein complex result in a lack of MHC class II and reduced MHC class I cell surface expression. Using type III BLS cell lines, we demonstrate that the RFX subunits RFX5 and RFXAP are crucial for constitutive and CIITA-induced MHC class I and beta(2)m transactivation. Similar to MHC class II, the promoters of MHC class I and beta(2)m contain lan S-X-Y region of which the X1 box is crucial for constitutive and CIITA-induced MHC class I and beta(2)m transactivation. Thus, the RFX complex is part of a regulatory pathway linking the transactivation of MHC class I and II and their accessory genes.

引用

页码：531 / 541

页数：11