Preparation of spherical monodisperse ferrimagnetic iron-oxide microparticles between 1 and 5 μm diameter

被引:16
作者
Möller, W
Scheuch, G
Sommerer, K
Heyder, J
机构
[1] GSF Natl Res Ctr Environm & Hlth, Inst Inhalat Biol, D-82131 Gauting, Germany
[2] InAMed Inst Aerosol Med GmbH, D-82131 Gauting, Germany
关键词
iron-oxide particles; spherical; monodisperse; ferrimagnetic; spinning top aerosol generator; nebulization; technetium-99m (Tc-99 m); radiolabeling; magnetite; preparation; indium-111 (In-111); lung imaging; cell motility; alveolar clearance;
D O I
10.1016/S0304-8853(00)01221-X
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The production of spherical monodisperse iron-oxide microparticles in the size range between 0.8 and 5 mum is described. The particles can be ferrimagnetic (Fe3O4) or non-magnetic (alpha -Fe2O3). The particles were radiolabeled with Te-99m or In-111, and the leakage of the radiolabel within 24 h was 0.1% in the human lung. The particles can be used to study the motility and the integrity of living cells. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:8 / 16
页数:9
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