Resolution of omeprazole by inclusion complexation with a chiral host BINOL

被引:52
作者
Deng, JG [1 ]
Chi, YX [1 ]
Fu, FM [1 ]
Cui, X [1 ]
Yu, KB [1 ]
Zhu, J [1 ]
Jiang, YZ [1 ]
机构
[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China
基金
中国国家自然科学基金;
关键词
D O I
10.1016/S0957-4166(00)00114-2
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Both (S)-(-)- and (R)-(+)-enantiomers of omeprazole were directly resolved by inclusion complexation with a chiral host compound (S)-(-)- or (R)-(+)-2,2'-dihydroxy-1,1'-binaphthyl in high enantiomeric excess (> 99% e.e.). (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1729 / 1732
页数:4
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