Transformation of isoxanthohumol by fungi

被引：34

作者：

Bartmanska, Agnieszka ^{[1
]}

Huszcza, Ewa ^{[1
]}

Tronina, Tomasz ^{[1
]}

机构：

[1] Univ Wroclaw Environm & Life Sci, Dept Chem, PL-50375 Wroclaw, Poland

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2009年 / 61卷 / 3-4期

关键词：

Isoxanthohumol; Biotransformation; Absidia glauca; Beauveria bassiana; Fusarium equiseti; HOPS HUMULUS-LUPULUS; MICROBIAL-METABOLISM; IN-VITRO; POTENT PHYTOESTROGEN; BIOLOGICAL-ACTIVITY; XANTHOHUMOL; L; PRENYLFLAVONOIDS; IDENTIFICATION; BEER;

D O I：

10.1016/j.molcatb.2009.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Isoxanthohumol is the most abundant and an important prenylated flavonoid present in hopped beers. In order to select microorganisms capable of transforming isoxanthohumol screening tests on 44 fungi cultures were performed. This kind of activity has not been previously examined. Beauveria bassiana AM278 and Absidia glauca AM 177 converted isoxanthohumol into glucoside derivatives, whereas Fusarium equiseti AM15 transformed it into (2R)-2 ''-(2 '''-hydroxyisopropyl)-dihydrofurano[2 '',3 '':7,8]-4 '-hydroxy-5-methoxyflavanone with high efficiency. Isoxanthohumol 7-O-beta-D-4 '''-methoxyglucopyranoside is a new compound. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：221 / 224

页数：4

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