Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae

被引：21

作者：

Bast, DJ

de Azavedo, JCS

Tam, TY

Kilburn, L

Duncan, C

Mandell, LA

Davidson, RJ

Low, DE

机构：

[1] Mt Sinai Hosp, Dept Microbiol, Toronto, ON M5G 1X5, Canada

[2] Torento Med Labs, Dept Microbiol, Toronto, ON M5G 1X5, Canada

[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[4] McMaster Univ, Div Infect Dis, Hamilton, ON L8S 4L8, Canada

[5] Hamilton Hlth Serv Corp, Hamilton, ON, Canada

[6] Dalhousie Univ, Dept Microbiol, Queen Elizabeth II Sci Ctr, Halifax, NS, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 09期

关键词：

D O I：

10.1128/AAC.45.9.2631-2634.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Analysis of 71 ciprofloxacin-resistant (MIC greater than or equal to 4 mug/ml) Streptococcus pneumoniae clinical isolates revealed only I for which the quinolone resistance-determining regions of the parC, parE, and rB genes were genetically related to those of viridans group streptococci. Our findings support the occurrence of interspecies recombination of type II topoisomerase genes; however, its contribution to the emergence of quinolone resistance among pneumococci appears to have been minimal.

引用

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页码：2631 / 2634

页数：4

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