Progesterone enhances prostaglandin E2 production via interaction with nitric oxide in the mouse acrosome reaction

被引：15

作者：

Herrero, MB ^{[1
]}

Cebral, E ^{[1
]}

Franchi, A ^{[1
]}

Motta, A ^{[1
]}

Gimeno, MF ^{[1
]}

机构：

[1] CONICET, CEFYBO, RA-1414 Buenos Aires, DF, Argentina

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 252卷 / 02期

关键词：

nitric oxide; prostaglandins; cGMP; acrosomal; exocytosis; spermatozoa; (Mouse);

D O I：

10.1006/bbrc.1998.9638

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study we evidenced that progesterone could directly stimulate sperm nitric oxide synthase (NOS) in capacitated mouse spermatozoa. This stimulation led to an increase in sperm prostaglandin E-2 (PGE(2)) production and subsequent acrosomal exocytosis. However, cGMP levels were not modified during the progesterone-induced acrosome reaction under our experimental conditions. These results suggest a functional role for nitric oxide as an intracellular messenger through, at least, stimulation of PGE(2) production during the acrosome reaction triggered by progesterone. (C) 1998 Academic Press.

引用

收藏

页码：324 / 328

页数：5

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