Studies of focal adhesion assembly

被引：26

作者：

Campbell, Iain D. ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

Dok1; fibronectin; filamin; focal adhesion; integrin; talin;

D O I：

10.1042/BST0360263

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies of some proteins involved in the formation of focal adhesions are described. These include fibronectin, integrins, talin, Dok1 and filamin. Emphasis is placed on features that facilitate regulated assembly of complexes; these include a modular construction and flexible regions that provide interaction sites whose affinity can be adjusted by conformational masking and phosphorylation.

引用

页码：263 / 266

页数：4

共 26 条

[1] Understanding the elasticity of fibronectin fibrils: Unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy [J].

Abu-Lail, NI ;

Ohashi, T ;

Clark, RL ;

Erickson, HP ;

Zauscher, S .

MATRIX BIOLOGY, 2006, 25 (03) :175-184

[2] The eighth FIII domain of human fibronectin promotes integrin α5β1 binding via stabilization of the ninth FIII domain [J].

Altroff, H ;

van der Walle, CF ;

Asselin, J ;

Fairless, R ;

Campbell, ID ;

Mardon, HJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38885-38892

[3] Interdomain tilt angle determines integrin-dependent function of the ninth and tenth FIII domains of human fibronectin [J].

Altroff, H ;

Schlinkert, R ;

van der Walle, CF ;

Bernini, A ;

Campbell, ID ;

Werner, JM ;

Mardon, HJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (53) :55995-56003

[4]

Campbell ID, 2003, BIOCHEM SOC T, V31, P1107

[5] The talin-tail interaction places integrin activation on FERM ground [J].

Campbell, ID ;

Ginsberg, MH .

TRENDS IN BIOCHEMICAL SCIENCES, 2004, 29 (08) :429-435

[6] Genetic, biochemical and structural approaches to talin function [J].

Critchley, DR .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 :1308-1312

[7] The molecular basis of filamin binding to integrins and competition with talin [J].

Kiema, T ;

Lad, Y ;

Jiang, PJ ;

Oxley, CL ;

Baldassarre, M ;

Wegener, KL ;

Campbell, ID ;

Ylänne, J ;

Calderwood, DA .

MOLECULAR CELL, 2006, 21 (03) :337-347

[8] Structure of three tandem filamin domains reveals auto-inhibition of ligand binding [J].

Lad, Yatish ;

Kiema, Tiila ;

Jiang, Pengju ;

Pentikaeinen, Olli T. ;

Coles, Charlotte H. ;

Campbell, Iain D. ;

Calderwood, David A. ;

Ylaenne, Jari .

EMBO JOURNAL, 2007, 26 (17) :3993-4004

[9] Integrin structures and conformational signaling [J].

Luo, Bing-Hao ;

Springer, Timothy A. .

CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (05) :579-586

[10] Fibronectin fibrillogenesis, a cell-mediated matrix assembly process [J].

Mao, Y ;

Schwarzbauer, JE .

MATRIX BIOLOGY, 2005, 24 (06) :389-399

← 1 2 3 →