Pancreatic ductal cells in development, regeneration, and neoplasia

被引：179

作者：

Reichert, Maximilian ^{[1
]}

Rustgi, Anil K. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Div Gastroenterol, Dept Med,Abramson Canc Ctr, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 12期

关键词：

PAPILLARY MUCINOUS NEOPLASMS; ADULT-MOUSE PANCREAS; CANCER STEM-CELLS; BETA-CELLS; PROGENITOR CELLS; ACINAR-CELLS; INTRAEPITHELIAL NEOPLASIA; IN-VITRO; EMBRYONIC PANCREAS; EXOCRINE PANCREAS;

D O I：

10.1172/JCI57131

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The pancreas is a complex organ comprised of three critical cell lineages: islet (endocrine), acinar, and ductal. This review will focus upon recent insights and advances in the biology of pancreatic ductal cells. In particular, emphasis will be placed upon the regulation of ductal cells by specific transcriptional factors during development as well as the underpinnings of acinar-ductal metaplasia as an important adaptive response during injury and regeneration. We also address the potential contributions of ductal cells to neoplastic transformation, specifically in pancreatic ductal adenocarcinoma.

引用

页码：4572 / 4578

页数：7

共 102 条

[11] Dynamics of the immune reaction to pancreatic cancer from inception to invasion [J].

Clark, Carolyn E. ;

Hingorani, Sunil R. ;

Mick, Rosemarie ;

Combs, Chelsea ;

Tuveson, David A. ;

Vonderheide, Robert H. .

CANCER RESEARCH, 2007, 67 (19) :9518-9527

[12] Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro -: A balance between proliferation and differentiation [J].

Cras-Méneur, C ;

Elghazi, L ;

Czernichow, P ;

Scharfmann, R .

DIABETES, 2001, 50 (07) :1571-1579

[13]

DELISLE RC, 1990, EUR J CELL BIOL, V51, P64

[14] The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter [J].

Deramaudt, Therese B. ;

Sachdeva, Mira M. ;

Wescott, Melanie P. ;

Chen, Yuting ;

Stoffers, Doris A. ;

Rustgi, Anil K. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (50) :38385-38395

[15] Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation [J].

Dor, Y ;

Brown, J ;

Martinez, OI ;

Melton, DA .

NATURE, 2004, 429 (6987) :41-46

[16] Dorsal pancreas agenesis in N-cadherin-deficient mice [J].

Esni, F ;

Johansson, BR ;

Radice, GL ;

Semb, H .

DEVELOPMENTAL BIOLOGY, 2001, 238 (01) :202-212

[17] Intraductal Papillary Mucinous Neoplasms of the Pancreas [J].

Fernandez-del Castillo, Carlos ;

Adsay, N. Volkan .

GASTROENTEROLOGY, 2010, 139 (03) :708-U31

[18] Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras [J].

Friedlander, Sharon Y. Gidekel ;

Chu, Gerald C. ;

Snyder, Eric L. ;

Girnius, Nomeda ;

Dibelius, Gregory ;

Crowley, Denise ;

Vasile, Eliza ;

DePinho, Ronald A. ;

Jacks, Tyler .

CANCER CELL, 2009, 16 (05) :379-389

[19] Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation [J].

Fujitani, Y ;

Fujitani, S ;

Boyer, DF ;

Gannon, M ;

Kawaguchi, Y ;

Ray, M ;

Shiota, M ;

Stein, RW ;

Magnuson, MA ;

Wright, CVE .

GENES & DEVELOPMENT, 2006, 20 (02) :253-266

[20] Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression [J].

Fukuda, Akihisa ;

Wang, Sam C. ;

Morris, John P. ;

Folias, Alexandra E. ;

Liou, Angela ;

Kim, Grace E. ;

Akira, Shizuo ;

Boucher, Kenneth M. ;

Firpo, Matthew A. ;

Mulvihill, Sean J. ;

Hebrok, Matthias .

CANCER CELL, 2011, 19 (04) :441-455

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