Transmembrane nanopores from porphyrin supramolecules

被引：55

作者：

Satake, Akiharu ^{[1
]}

Yamamura, Mika ^{[1
]}

Oda, Masafumi ^{[1
]}

Kobuke, Yoshiaki ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 630, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 20期

关键词：

D O I：

10.1021/ja801129a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A porphyrin-based nanopore was constructed through a bilayer lipid membrane (BLM). The macrocyclic porphyrin (the inner diameter = ca. 2.1 nm) having six carboxylic acid groups directed up and down was synthesized by self-assembly of three trisporphyrins, metathesis linking, and subsequent hydrolysis. The porphyrin was incorporated into soybean lecithin based BLM, and the ion currents through the nanopore were observed under 500 mM KCl, LiCl, CaCl(2), and tetraalkylammonium chloride solutions, indicating formation of a large pore through BLM. Blocking of the ion current was achieved by addition of the polycationic fourth-generation PAMAM dendrimer.

引用

页码：6314 / +

页数：3

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