Presenilins:: Members of the γ-secretase quartets, but part-time soloists too

被引：102

作者：

Wakabayashi, Tomoko ^{[1
,2
]}

De Strooper, Bart ^{[1
,2
]}

机构：

[1] VIB, Dept Dev & Mol Genet, Louvain, Belgium

[2] Katholieke Univ Leuven, Ctr Human Genet, Louvain, Belgium

来源：

PHYSIOLOGY | 2008年 / 23卷 / 04期

关键词：

D O I：

10.1152/physiol.00009.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The presenilins in combination with other proteins generate different gamma-secretases, which are involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding the specificity and regulation of these proteases will potentially lead to novel therapeutics for Alzheimer's disease and cancer. Presenilins appear also to exert additional functions outside of the gamma-secretase quartets, which needs further investigation.

引用

页码：194 / 204

页数：11

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