Sinulaflexiolides A-K, cembrane-type diterpenoids from the Chinese soft coral Sinularia flexibilis

被引：52

作者：

Wen, Ting ^{[1
]}

Ding, Yi ^{[2
]}

Deng, Zhiwei ^{[3
]}

van Ofwegen, Leen P. ^{[4
]}

Proksch, Peter ^{[5
]}

Lin, Wenhan ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China

[3] Beijing Normal Univ, Analyt & Testing Ctr, Beijing 100875, Peoples R China

[4] Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands

[5] Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 07期

关键词：

D O I：

10.1021/np070640g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A-K (1-11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 mu M, respectively.

引用

页码：1133 / 1140

页数：8

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