Notch and the birth of glial cells

被引：57

作者：

Lundkvist, J ^{[1
]}

Lendahl, U ^{[1
]}

机构：

[1] Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 09期

关键词：

D O I：

10.1016/S0166-2236(00)01888-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Notch receptors play crucial roles in many cellular differentiation programs. In addition to a more classical role for Notch in keeping cells in an undifferentiated state, a recent paper has provided clear evidence that Notch signaling is a powerful means of turning adult CNS precursor cells into astrocytes. This work, combined with other reports from the developing CNS, retina and the PNS, demonstrates a role for Notch in gliogenesis. These findings can also be linked to novel insights into the function of proneural basic helix-loop-helix proteins in astrocytic differentiation.

引用

页码：492 / 494

页数：3

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