Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona

被引：23

作者：

Bowers, Jolene R. ^{[1
]}

Driebe, Elizabeth M. ^{[1
]}

Nibecker, Jennifer L. ^{[1
]}

Wojack, Bette R. ^{[2
]}

Sarovich, Derek S. ^{[3
]}

Wong, Ada H. ^{[4
]}

Brzoska, Pius M. ^{[4
]}

Hubert, Nathaniel ^{[1
]}

Knadler, Andrew ^{[1
]}

Watson, Lindsey M. ^{[3
]}

Wagner, David M. ^{[3
]}

Furtado, Manohar R. ^{[4
]}

Saubolle, Michael ^{[2
,5
]}

Engelthaler, David M. ^{[1
]}

Keim, Paul S. ^{[1
,3
]}

机构：

[1] Translat Genom Res Inst, Flagstaff, AZ USA

[2] Lab Sci Arizona, Tempe, AZ USA

[3] No Arizona Univ, Flagstaff, AZ 86011 USA

[4] Life Technol, Foster City, CA USA

[5] Univ Arizona, Tucson, AZ USA

来源：

BMC MICROBIOLOGY | 2012年 / 12卷

关键词：

DETERMINING CAPSULAR SEROTYPES; SEQUENTIAL MULTIPLEX PCR; ERYTHROMYCIN RESISTANCE; ANTIBACTERIAL SUSCEPTIBILITY; MOLECULAR CHARACTERIZATION; ANTIMICROBIAL RESISTANCE; UNITED-STATES; ERM(B); PNEUMOCOCCI; ELEMENTS;

D O I：

10.1186/1471-2180-12-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them. Results: Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan(19F)-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains. Conclusions: The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.

引用

页数：10

共 49 条

[1] mef(A) is the predominant macrolide resistance determinant in Streptococcus pneumoniae and Streptococcus pyogenes in Germany [J].