NADPH oxidase

被引：56

作者：

Shatwell, KP

Segal, AW

机构：

[1] Department of Medicine, University College London, Rayne Institute, London WC1E 6JJ

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1996年 / 28卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S1357-2725(96)00084-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Superoxide is instrumental in the killing of microorganisms by phagocytic cells. It is generated by the NADPH oxidase system, a membrane-bound electron transport complex which pumps electrons from NADPH in the cytoplasm across the wall of the phagocytic vacuole to molecular oxygen. Superoxide deficiency results in the genetically inherited condition Chronic Granulomatous Disease (CGD), in which the patient is abnormally susceptible to infection. In recent years many of the underlying genetic defects in CGD have been identified and are providing important insights into the structure and mechanism of the NADPH oxidase complex. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1191 / 1195

页数：5

共 10 条

[1] ACTIVATION OF NADPH OXIDASE INVOLVES THE DISSOCIATION OF P21(RAC) FROM ITS INHIBITORY GDP/GTP EXCHANGE PROTEIN (RHOGDI) FOLLOWED BY ITS TRANSLOCATION TO THE PLASMA-MEMBRANE [J].