Retinoic acid signals the direction of ocular elongation in the guinea pig eye

被引：188

作者：

McFadden, SA ^{[1
]}

Howlett, MHC

Mertz, JR

机构：

[1] Univ Newcastle, Fac Sci, Sch Behav Sci, Newcastle, NSW 2308, Australia

[2] Univ Newcastle, IT, Newcastle, NSW 2308, Australia

[3] New England Coll Optometry, Boston, MA 02115 USA

来源：

VISION RESEARCH | 2004年 / 44卷 / 07期

关键词：

retinoid; myopia; emmetropization; growth; rodent;

D O I：

10.1016/j.visres.2003.11.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A growing eye becomes myopic after form deprivation (FD) or compensates for the power and sign of imposed spectacle lenses. A possible mediator of the underlying growth changes is all-trans retinoic acid (RA). Eye elongation and refractive error (RE) was manipulated by raising guinea pigs with FD, or a spectacle lens worn on one eye. We found retinal-RA increased in myopic eyes with accelerated elongation and was lower in eyes with inhibited elongation. RA levels in the choroid/sclera combined mirrored these directional changes. Feeding RA (25 mg/kg) repeatedly to guinea pigs, also resulted in rapid eye elongation (up to 5 times normal), and yet the RE was not effected. In conclusion, RA may act as a signal for the direction of ocular growth. Crown Copyright (C) 2003 Published by Elsevier Ltd. All rights reserved.

引用

页码：643 / 653

页数：11

共 44 条

[11]

Guggenheim JA, 1996, INVEST OPHTH VIS SCI, V37, P1380

[12]

Howlett MC., 2002, INVEST OPHTHALMOL VI, V43, P2928

[13]

HOWLETT MHC, 2003, THESIS U NEWCASTLE A, P1

[14] SPECTACLE LENSES ALTER EYE GROWTH AND THE REFRACTIVE STATUS OF YOUNG MONKEYS [J].

HUNG, LF ;

CRAWFORD, MLJ ;

SMITH, EL .

NATURE MEDICINE, 1995, 1 (08) :761-765

[15]

IRVING EL, 1992, OPHTHAL PHYSL OPT, V12, P448, DOI 10.1111/j.1475-1313.1992.tb00315.x

[16]

Kee CS, 2001, INVEST OPHTH VIS SCI, V42, P575

[17]

LODGE A, 1994, P AUSTR NEUROSCIENCE, V5, P123

[18]

Marzani D, 1997, INVEST OPHTH VIS SCI, V38, P1726

[19]

McBrien NA, 2000, INVEST OPHTH VIS SCI, V41, P3713

[20]

MCFADDEN S, 1995, INVEST OPHTH VIS SCI, V36, pS758

← 1 2 3 4 5 →