Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder

被引：132

作者：

Oddiah, D

Anand, P

McMahon, SB

Rattray, M ^{[1
]}

机构：

[1] United Med & Dent Sch Guys & St Thomas Hosp, Guys Hosp, Div Biochem & Mol Biol, Biochem Neuropharmacol Grp, London SE1 9RT, England

[2] Royal London Hosp, London Hosp, Coll Med, Dept Neurol, London E1 1BB, England

[3] United Med & Dent Guys & St Thomas Hosp, St Thomas Hosp, Div Physiol, London SE1 9RT, England

来源：

NEUROREPORT | 1998年 / 9卷 / 07期

关键词：

cystitis; hyperalgesia; inflammation; nerve growth factor; neurotrophins; rat; RT-PCR; turpentine; urinary bladder; visceral pain;

D O I：

10.1097/00001756-199805110-00038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NERVE growth factor (NGF) is a mediator of hyperalgesia and has been previously associated with sensory and reflex changes after inflammation of the urinary bladder. A sensitive assay was developed to examine neurotrophin gene expression after bladder inflammation by turpentine, which causes a short-lived inflammatory response. Two hours, but not 6 or 24 h after induction of inflammation, there were significant increases in levels of NGF, brain-derived neurotrophic factor and neurotrophin-3 mRNAs. NGF immunoreactivity was elevated with a similar time course to its mRNA. Our results suggest that during bladder inflammation, endogenous NGF is rapidly up-regulated and released to mediating sensory and reflex changes. Brain-derived neurotrophic factor and neurotrophin-3 may also have a role in the inflammatory response. (C) 1998 Rapid Science Ltd.

引用

页码：1455 / 1458

页数：4