Rapid microwave-assisted solid-phase glycopeptide synthesis

被引：108

作者：

Matsushita, T

Hinou, H

Kurogochi, M

Shimizu, H

Nishimura, SI

机构：

[1] Hokkaido Univ, Frontier Res Ctr Post Genome Sci & Technol, Grad Sch Sci, Div Biol Sci, Sapporo, Hokkaido 0010021, Japan

[2] Natl Inst Adv Ind Sci & Technol, Res Ctr Glycosci, Glycochemosynt Team, Sapporo, Hokkaido 0628517, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 05期

关键词：

D O I：

10.1021/ol0474352

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Coupling of glycosylated Fmoc-Thr or Fmoc-Ser with N-terminal amino acids on a resin proceeded smoothly under microwave irradiation for 20 min with much higher efficiency (98% yield per coupling) than found in more general conditions. Compared with a conventional protocol, the present method greatly reduces the time required for solid-phase glycopeptide synthesis from 4 days to 7 h, as is the case with the synthesis of Muc-1-related 20-residue glycopeptide carrying five core-2 trisaccharide chains.

引用

页码：877 / 880

页数：4

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