The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation

被引：104

作者：

Marston, AL ^{[1
]}

Lee, BH ^{[1
]}

Amon, A ^{[1
]}

机构：

[1] MIT, Howard Hughes Med Inst, Canc Res Ctr, Cambridge, MA 02139 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1534-5807(03)00130-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During meiosis, DNA replication is followed by two consecutive rounds of chromosome segregation. Cells lacking the protein phosphatase CDC14 or its regulators, SPO12 and SLK19, undergo only a single meiotic division, with some chromosomes segregating reductionally and others equationally. We find that this abnormal chromosome behavior is due to an uncoupling of meiotic events. Anaphase I spindle disassembly is delayed in cdc14-1, slk19Delta, or spo12Delta mutants, but the chromosome segregation cycle continues, so that both meiotic chromosome segregation phases take place on the persisting meiosis I spindle. Our results show that Cdc14, Slk19, and Spo12 are not only required for meiosis I spindle disassembly but also play a pivotal role in establishing two consecutive chromosome segregation phases, a key feature of the meiotic cell cycle.

引用

页码：711 / 726

页数：16