1,3,4-Thiadiazole-2,5-bissulfonamide was prepared from 2,5-dimercapto-1,3,4-thiadiazole, by a modification of the reported literature procedure, ie, via the sulfenamide. This compound is the lead molecule for designing important classes of pharmacological agents, such as benzothiadiazine diuretics, and it seems to behave as a strong inhibitor of the zinc enzyme carbonic anhydrase (CA). Here we prove that the title compound is actually a weak CA inhibitor and try to explain why previous investigators obtained erroneous data.