Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles

被引：816

作者：

Yang, Kai ^{[1
]}

Hu, Lilei ^{[1
]}

Ma, Xingxing ^{[2
]}

Ye, Shuoqi ^{[3
]}

Cheng, Liang ^{[1
]}

Shi, Xiaoze ^{[1
]}

Li, Changhui ^{[3
]}

Li, Yonggang ^{[2
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat Lab FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Radiol, Suzhou 215006, Jiangsu, Peoples R China

[3] Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 14期

基金：

中国国家自然科学基金;

关键词：

graphene oxide nanocomposites; magnetic resonance imaging; photoacoustic imaging; photothermal therapy; multimodal imaging; GOLD NANOCAGES; CARBON NANOTUBES; CANCER-THERAPY; DRUG-DELIVERY; OXIDE; PLATFORM; LONG; MICE; FABRICATION; OXIDATION;

D O I：

10.1002/adma.201104964

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this work, a nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO-IONP-PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1868 / 1872

页数：5

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