Recent advances in the molecular pathophysiology of atrial fibrillation

被引：467

作者：

Wakili, Reza ^{[1
,2
,3
]}

Voigt, Niels ^{[4
]}

Kaeaeb, Stefan ^{[3
]}

Dobrev, Dobromir ^{[4
]}

Nattell, Stanley ^{[1
,2
]}

机构：

[1] Montreal Heart Inst, Dept Med, Res Ctr, Montreal, PQ H1T 1C8, Canada

[2] Univ Montreal, Montreal, PQ, Canada

[3] Univ Munich, Klinikum Grosshadern, Dept Med 1, D-8000 Munich, Germany

[4] Heidelberg Univ, Med Fac Mannheim, Div Expt Cardiol, D-6800 Mannheim, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 08期

基金：

加拿大健康研究院;

关键词：

OF-FUNCTION MUTATION; TISSUE GROWTH-FACTOR; VALVULAR HEART-DISEASE; LONG-QT SYNDROME; RYANODINE RECEPTOR; DOWN-REGULATION; POTASSIUM CURRENT; POTENTIAL ROLE; CONTRACTILE DYSFUNCTION; DEPENDENT REGULATION;

D O I：

10.1172/JCI46315

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia. We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding.

引用

页码：2955 / 2968

页数：14

共 150 条

[1] Rac1-Induced Connective Tissue Growth Factor Regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation [J].

Adam, Oliver ;

Lavall, Daniel ;

Theobald, Katharina ;

Hohl, Mathias ;

Grube, Markus ;

Ameling, Sabine ;

Sussman, Mark A. ;

Rosenkranz, Stephan ;

Kroemer, Heyo K. ;

Schaefers, Hans-Joachim ;

Boehm, Michael ;

Laufs, Ulrich .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (05) :469-480

[2] Connective-tissue growth factor - a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats [J].

Ahmed, MS ;

Oie, E ;

Vinge, LE ;

Yndestad, A ;

Andersen, GO ;

Andersson, Y ;

Attramadal, T ;

Attramadal, H .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 36 (03) :393-404

[3]

Allessie MA, 2001, CIRCULATION, V103, P769

[4] Selective Molecular Potassium Channel Blockade Prevents Atrial Fibrillation [J].

Amit, Guy ;

Kikuchi, Kan ;

Greener, Ian D. ;

Yang, Lizhu ;

Novack, Victor ;

Donahue, J. Kevin .

CIRCULATION, 2010, 121 (21) :2263-2270

[5] Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-Segment elevation, short QT intervals, and sudden cardiac death [J].

Antzelevitch, Charles ;

Pollevick, Guido D. ;

Cordeiro, Jonathan M. ;

Casis, Oscar ;

Sanguinetti, Michael C. ;

Aizawa, Yoshiyasu ;

Guerchicoff, Alejandra ;

Pfeiffer, Ryan ;

Oliva, Antonio ;

Wollnik, Bernd ;

Gelber, Philip ;

Bonaros, Elias P., Jr. ;

Burashnikov, Elena ;

Wu, Yuesheng ;

Sargent, John D. ;

Schickel, Stefan ;

Oberheiden, Ralf ;

Bhatia, Atul ;

Hsu, Li-Fern ;

Haissaguerre, Michel ;

Schimpf, Rainer ;

Borggrefe, Martin ;

Wolpert, Christian .

CIRCULATION, 2007, 115 (04) :442-449

[6] Subclinical hyperthyroidism as a risk factor for atrial fibrillation [J].

Auer, J ;

Scheibner, P ;

Mische, T ;

Langsteger, W ;

Eber, O ;

Eber, B .

AMERICAN HEART JOURNAL, 2001, 142 (05) :838-842

[7] Reverse structural and gap-junctional remodeling after prolonged atrial fibrillation in the goat [J].

Ausma, J ;

van der Velden, HMW ;

Lenders, MH ;

van Ankeren, EP ;

Jongsma, HJ ;

Ramaekers, FCS ;

Borgers, M ;

Allessie, MA .

CIRCULATION, 2003, 107 (15) :2051-2058

[8] Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry [J].

Benjamin, Emelia J. ;

Rice, Kenneth M. ;

Arking, Dan E. ;

Pfeufer, Arne ;

van Noord, Charlotte ;

Smith, Albert V. ;

Schnabel, Renate B. ;

Bis, Joshua C. ;

Boerwinkle, Eric ;

Sinner, Moritz F. ;

Dehghan, Abbas ;

Lubitz, Steven A. ;

D'Agostino, Ralph B., Sr. ;

Lumley, Thomas ;

Ehret, Georg B. ;

Heeringa, Jan ;

Aspelund, Thor ;

Newton-Cheh, Christopher ;

Larson, Martin G. ;

Marciante, Kristin D. ;

Soliman, Elsayed Z. ;

Rivadeneira, Fernando ;

Wang, Thomas J. ;

Eiriksdottir, Gudny ;

Levy, Daniel ;

Psaty, Bruce M. ;

Li, Man ;

Chamberlain, Alanna M. ;

Hofman, Albert ;

Vasan, Ramachandran S. ;

Harris, Tamara B. ;

Rotter, Jerome I. ;

Kao, W. H. Linda ;

Agarwal, Sunil K. ;

Stricker, Bruno H. Ch ;

Wang, Ke ;

Launer, Lenore J. ;

Smith, Nicholas L. ;

Chakravarti, Aravinda ;

Uitterlinden, Andre G. ;

Wolf, Philip A. ;

Sotoodehnia, Nona ;

Koettgen, Anna ;

van Duijn, Cornelia M. ;

Meitinger, Thomas ;

Mueller, Martina ;

Perz, Siegfried ;

Steinbeck, Gerhard ;

Wichmann, H-Erich ;

Lunetta, Kathryn L. .

NATURE GENETICS, 2009, 41 (08) :879-881

[9] Prevention of Atrial Fibrillation Report From a National Heart, Lung, and Blood Institute Workshop [J].

Benjamin, Emelia J. ;

Chen, Peng-Sheng ;

Bild, Diane E. ;

Mascette, Alice M. ;

Albert, Christine M. ;

Alonso, Alvaro ;

Calkins, Hugh ;

Connolly, Stuart J. ;

Curtis, Anne B. ;

Darbar, Dawood ;

Ellinor, Patrick T. ;

Go, Alan S. ;

Goldschlager, Nora F. ;

Heckbert, Susan R. ;

Jalife, Jose ;

Kerr, Charles R. ;

Levy, Daniel ;

Lloyd-Jones, Donald M. ;

Massie, Barry M. ;

Nattel, Stanley ;

Olgin, Jeffrey E. ;

Packer, Douglas L. ;

Po, Sunny S. ;

Tsang, Teresa S. M. ;

Van Wagoner, David R. ;

Waldo, Albert L. ;

Wyse, D. George .

CIRCULATION, 2009, 119 (04) :606-618

[10] Frequency-dependent breakdown of wave propagation into fibrillatory conduction across the pectinate muscle network in the isolated sheep right atrium [J].

Berenfeld, O ;

Zaitsev, AV ;

Mironov, SF ;

Pertsov, AM ;

Jalife, J .

CIRCULATION RESEARCH, 2002, 90 (11) :1173-1180

← 1 2 3 4 5 6 7 8 9 10 →