Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

被引：301

作者：

Benjamin, Emelia J. ^{[1
,2
,3
,4
]}

Rice, Kenneth M. ^{[5
]}

Arking, Dan E. ^{[6
]}

Pfeufer, Arne ^{[7
,8
]}

van Noord, Charlotte ^{[9
,10
,11
]}

Smith, Albert V. ^{[12
]}

Schnabel, Renate B. ^{[1
,13
]}

Bis, Joshua C. ^{[14
]}

Boerwinkle, Eric ^{[15
,16
]}

Sinner, Moritz F. ^{[17
]}

Dehghan, Abbas ^{[9
]}

Lubitz, Steven A. ^{[18
,19
]}

D'Agostino, Ralph B., Sr. ^{[1
,20
]}

Lumley, Thomas ^{[5
]}

Ehret, Georg B. ^{[6
]}

Heeringa, Jan ^{[9
]}

Aspelund, Thor ^{[12
,21
]}

Newton-Cheh, Christopher ^{[1
,19
,22
]}

Larson, Martin G. ^{[1
,20
]}

Marciante, Kristin D. ^{[23
,24
]}

Soliman, Elsayed Z. ^{[25
]}

Rivadeneira, Fernando ^{[9
,26
]}

Wang, Thomas J. ^{[1
,27
]}

Eiriksdottir, Gudny ^{[12
]}

Levy, Daniel ^{[1
,2
,3
,28
]}

Psaty, Bruce M. ^{[14
,23
,29
,30
,31
]}

Li, Man ^{[32
]}

Chamberlain, Alanna M. ^{[33
]}

Hofman, Albert ^{[9
]}

Vasan, Ramachandran S. ^{[1
,2
,3
]}

Harris, Tamara B. ^{[34
]}

Rotter, Jerome I. ^{[35
]}

Kao, W. H. Linda ^{[32
]}

Agarwal, Sunil K. ^{[36
]}

Stricker, Bruno H. Ch ^{[9
,26
,37
]}

Wang, Ke ^{[38
]}

Launer, Lenore J. ^{[34
]}

Smith, Nicholas L. ^{[29
,39
]}

Chakravarti, Aravinda ^{[6
]}

Uitterlinden, Andre G. ^{[9
,26
,40
]}

Wolf, Philip A. ^{[1
,41
]}

Sotoodehnia, Nona ^{[23
,42
]}

Koettgen, Anna ^{[32
]}

van Duijn, Cornelia M. ^{[9
]}

Meitinger, Thomas ^{[7
]}

Mueller, Martina ^{[17
,43
]}

Perz, Siegfried ^{[44
]}

Steinbeck, Gerhard ^{[17
]}

Wichmann, H-Erich ^{[43
,45
]}

Lunetta, Kathryn L. ^{[1
,38
]}

机构：

[1] NHLBI, Framingham Heart Study, Framingham, MA USA

[2] Boston Univ, Sch Med, Dept Med, Cardiol Sect, Boston, MA 02118 USA

[3] Boston Univ, Sch Med, Dept Med, Prevent Med Sect, Boston, MA 02118 USA

[4] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[5] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[6] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA

[7] Tech Univ Munich, Klinikum Rechts Isar, Dept Human Genet, D-8000 Munich, Germany

[8] German Natl Res Ctr Environm Hlth, Helmholtz Ctr Munich, Dept Human Genet, Munich, Germany

[9] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[10] Dutch Med Evaluat Board, The Hague, Netherlands

[11] Netherlands Consortium Healthy Aging, Leiden, Netherlands

[12] Iceland Heart Assoc, Kopavogur, Iceland

[13] Johannes Gutenberg Univ Mainz, Gutenberg Heart Study, Med Clin Cardiol 2, Mainz, Germany

[14] Univ Washington, Dept Med, Seattle, WA USA

[15] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX USA

[16] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Houston, TX USA

[17] Univ Munich, Klinikum Grosshadern, Dept Med 1, D-8000 Munich, Germany

[18] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA

[19] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA

[20] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA

[21] Univ Iceland, Reykjavik, Iceland

[22] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[23] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[24] Univ Washington, Dept Gen Internal Med, Seattle, WA 98195 USA

[25] Wake Forest Univ, Bowman Gray Sch Med, Dept Epidemiol & Prevent, Epidemiol Cardiol Res Ctr EPICARE, Winston Salem, NC USA

[26] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[27] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA

[28] NHLBI, Ctr Populat Studies, Bethesda, MD 20892 USA

[29] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[30] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

[31] Ctr Hlth Studies, Grp Hlth, Washington, DC USA

[32] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA

[33] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[34] NIA, Intramural Res Program, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[35] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

[36] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[37] Inspectorate Hlth Care, The Hague, Netherlands

[38] Boston Univ, Sch Med, Dept Biostat, Boston, MA 02118 USA

[39] Seattle Epidemiol Res & Informat Ctr, Dept Vet Affairs, Off Res & Dev, Seattle, WA USA

[40] Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands

[41] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[42] Univ Washington, Div Cardiol, Seattle, WA 98195 USA

[43] Deutsch Forschungszentrum Gesundheit & Umwelt, Inst Epidemiol, Helmholtz Zentrum Munchen, Munich, Germany

[44] Deutsch Forschungszentrum Gesundheit & Umwelt Gmb, Inst Med Informat, Helmholtz Zentrum Munchen, Neuherberg, Germany

[45] Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany

[46] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cardiac Arrhythmia Serv, Boston, MA USA

来源：

NATURE GENETICS | 2009年 / 41卷 / 08期

关键词：

TRANSCRIPTION FACTOR ATBF1; LIFETIME RISK; DIFFERENTIATION; PREVALENCE;

D O I：

10.1038/ng.416

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

引用

页码：879 / 881

页数：3

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