Extending the scope of native chemical peptide coupling

被引：53

作者：

Haase, Christian ^{[1
]}

Seitz, Oliver ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 09期

关键词：

auxiliaries; desulfurization; native chemical ligation; peptides; thioesters;

D O I：

10.1002/anie.200704886

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The two bottlenecks for native chemical ligation are the limitations of thioester syntheses and a lack of suitable coupling sites in peptide sequences. This Highlight describes current advances that are capable of extending the scope of these methods, such as radical desulfurization (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：1553 / 1556

页数：4

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