Biomedical applications of boronic acid polymers

被引：365

作者：

Cambre, Jennifer N. ^{[1
]}

Sumerlin, Brent S. ^{[1
]}

机构：

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

来源：

POLYMER | 2011年 / 52卷 / 21期

基金：

美国国家科学基金会;

关键词：

Boronic acid; Glucose sensors; Insulin delivery; HIV inhibition; Lipase inhibition; LIVING RADICAL POLYMERIZATION; GLUCOSE-RESPONSIVE MICROGELS; NEUTRON-CAPTURE THERAPY; POLYANILINE/CARBON NANOTUBE COMPOSITE; ORGANOBORON QUINOLATE POLYMERS; INDUCED CONFORMATIONAL-CHANGES; FRAGMENTATION CHAIN TRANSFER; INSULIN DELIVERY-SYSTEM; CROSS-LINKED HYDROGEL; PHENYLBORONIC ACID;

D O I：

10.1016/j.polymer.2011.07.057

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Boron-containing organic compounds have found widespread use in synthetic organic chemistry. More recently, boronic acid-containing polymers have proven valuable in a variety of biomedical applications, including the treatment of HIV, obesity, diabetes, and cancer. However, as compared to many other classes of functional polymers, boronic acid-containing (co)polymers remain underutilized, despite their unique reactivity, solubility, and responsive nature. This Feature Article highlights research in this area, with particular focus on recent developments in synthesis, processing, and materials development that have enabled the preparation of new biomaterials. In addition to providing an overview to the current state of the art, we emphasize the versatility of boronic acid polymers and suggest routes for their further employment in other potential biomedical applications. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4631 / 4643

页数：13

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