A Molecular Probe for the Highly Selective Chromogenic Detection of DFP, a Mimic of Sarin and Soman Nerve Agents

被引：64

作者：

Gotor, Raul ^{[1
]}

Costero, Ana M. ^{[1
]}

Gil, Salvador ^{[1
]}

Parra, Margarita ^{[1
]}

Martinez-Manez, Ramon ^{[2
]}

Sancenon, Felix ^{[2
]}

机构：

[1] Univ Valencia, Ctr Reconocimiento Mol & Desarrollo Tecnol, Unidad Mixta, Univ Politecn Valencia,Dept Quim Organ,Fac Cienci, E-46100 Valencia, Spain

[2] Univ Politecn Valencia, Ctr Reconocimiento Mol & Desarrollo Tecnol, Unidad Mixta, Univ Valencia,Dept Quim, Valencia 46022, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 43期

关键词：

chemosensors; chromogenic detection; DFP recognition; nerve-agent simulants; organophosphonates; CHEMICAL WARFARE AGENTS; FLUORESCENT SENSORS; IMPRINTED POLYMERS; SIMULANTS; ARRAYS; NANOPARTICLES; INHIBITION; BIOSENSORS; SURFACE; GROWTH;

D O I：

10.1002/chem.201102241

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Lethal-weapon visualization: A novel triarylmethanol derivative, which is able to colorimetrically distinguish diisopropylfluorophosphate (DFP; a mimic of Sarin and Soman) from other nerve-agent simulants, is reported (see picture). This probe was designed to contain two reactive sites: an OH group that provides a suitable reactive group for nerve agents and a tert-butyldimethylsilylether moiety that is able to react with fluoride, which is a specific byproduct of the phosphorylation of OH by DFP. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11994 / 11997

页数：4

共 48 条

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Biosensors based on cholinesterase inhibition for insecticides, nerve agents and aflatoxin B1 detection (review) [J].