Serum 25-hydroxyvitamin D, vitamin A, and lung cancer mortality in the US population: a potential nutrient-nutrient interaction

被引:36
作者
Cheng, Ting-Yuan David [1 ,2 ]
Neuhouser, Marian L. [1 ,2 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
[2] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
关键词
Serum 25-hydroxyvitamin D; Retinol; Retinyl esters; Lung cancer; The Third National Health and Nutrition Examination Survey (NHANES III); NUTRITION-EXAMINATION-SURVEY; SQUAMOUS-CELL CARCINOMA; SMOKING-CESSATION; NATIONAL-HEALTH; IN-VITRO; RISK; ANGIOGENESIS; EXPRESSION; PROSTATE; DISEASE;
D O I
10.1007/s10552-012-0033-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Excess vitamin A may interrupt vitamin D-mediated transcription of target genes. This study investigated whether serum 25-hydroxyvitamin D [25(OH)D] concentrations were associated with lung cancer mortality, and whether this association varied by excess circulating vitamin A and vitamin A/beta-carotene supplement use. We analyzed 16,693 men and women in the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. Lung cancer mortality (n = 258, 104 were former smokers and 23 were never smokers) were identified through National Death Index as of 2006. Serum 25(OH)D was measured by a radioimmunoassay. Vitamin A biomarkers including serum retinol, beta-carotene, and retinyl esters were measured by HPLC. Supplement use for the past month was obtained by self-report. Multivariate-adjusted hazard ratios (HR) were estimated by Cox proportional hazard models. There was no association of serum 25(OH)D with overall lung cancer mortality. Among nonsmokers, >= 44 vs. < 44 nmol/L of serum 25(OH)D was associated with a decreased risk (HR = 0.53, 95 % CI = 0.31-0.92, former/never smokers and HR = 0.31, 95 % CI = 0.13-0.77, distant-former [quit >= 20 years]/never smokers). The associations were not observed among participants with excess circulating vitamin A (serum retinyl esters >= 7.0 mu g/dL or the ratio of retinyl esters to retinol >= 0.08) or vitamin A/beta-carotene supplement users. However, statistical evidence to support effect modification of vitamin A was less clear. Serum 25(OH)D concentrations were inversely associated with lung cancer mortality in nonsmokers. The beneficial association was diminished among those with excess circulating vitamin A or vitamin A/beta-carotene supplement users.
引用
收藏
页码:1557 / 1565
页数:9
相关论文
共 42 条
[1]
Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption [J].
Arnhold, T ;
Tzimas, G ;
Wittfoht, W ;
Plonait, S ;
Nau, H .
LIFE SCIENCES, 1996, 59 (12) :PL169-PL177
[2]
Dietary Supplement Use in the United States, 2003-2006 [J].
Bailey, Regan L. ;
Gahche, Jaime J. ;
Lentino, Cindy V. ;
Dwyer, Johanna T. ;
Engel, Jody S. ;
Thomas, Paul R. ;
Betz, Joseph M. ;
Sempos, Christopher T. ;
Picciano, Mary Frances .
JOURNAL OF NUTRITION, 2011, 141 (02) :261-266
[3]
High serum retinyl esters are not associated with reduced bone mineral density in the Third National Health and Nutrition Examination Survey, 1988-1994 [J].
Ballew, C ;
Galuska, D ;
Gillespie, C .
JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (12) :2306-2312
[4]
1α, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis [J].
Bao, Bo-Ying ;
Yao, Jorge ;
Lee, Yi-Fen .
CARCINOGENESIS, 2006, 27 (09) :1883-1893
[5]
Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies [J].
Bao, Y. ;
Ng, K. ;
Wolpin, B. M. ;
Michaud, D. S. ;
Giovannucci, E. ;
Fuchs, C. S. .
BRITISH JOURNAL OF CANCER, 2010, 102 (09) :1422-1427
[6]
CYP24A1 Is an Independent Prognostic Marker of Survival in Patients with Lung Adenocarcinoma [J].
Chen, Guoan ;
Kim, So Hee ;
King, Amanda N. ;
Zhao, Lili ;
Simpson, Robert U. ;
Christensen, Paul J. ;
Wang, Zhuwen ;
Thomas, Dafydd G. ;
Giordano, Thomas J. ;
Lin, Lin ;
Brenner, Dean E. ;
Beer, David G. ;
Ramnath, Nithya .
CLINICAL CANCER RESEARCH, 2011, 17 (04) :817-826
[7]
A modified least-squares regression approach to the estimation of risk difference [J].
Cheung, Yin Bun .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 166 (11) :1337-1344
[8]
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics [J].
Deeb, Kristin K. ;
Trump, Donald L. ;
Johnson, Candace S. .
NATURE REVIEWS CANCER, 2007, 7 (09) :684-700
[9]
Lung cancer risk reduction after smoking cessation: Observations from a prospective cohort of women [J].
Ebbert, JO ;
Yang, P ;
Vachon, CM ;
Vierkant, RA ;
Cerhan, JR ;
Folsom, AR ;
Sellers, TA .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (05) :921-926
[10]
Prospective study of serum vitamin D and cancer mortality in the United States [J].
Freedman, D. Michal ;
Looker, Anne C. ;
Chang, Shih-Chen ;
Graubard, Barry I. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (21) :1594-1602