Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies

被引:61
作者
Bao, Y. [1 ]
Ng, K. [2 ]
Wolpin, B. M. [2 ]
Michaud, D. S. [3 ,4 ]
Giovannucci, E. [1 ,3 ,5 ]
Fuchs, C. S. [1 ,2 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Channing Lab,Dept Med, Boston, MA 02115 USA
[2] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[4] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England
[5] Harvard Univ, Dept Nutr, Sch Publ Hlth, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
vitamin D; pancreatic cancer; epidemiology; UNITED-STATES; MALE SMOKERS; MORTALITY; MEN;
D O I
10.1038/sj.bjc.6605658
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: Studies evaluating vitamin D status in relation to pancreatic cancer risk have yielded inconsistent results. METHODS: We prospectively followed 118 597 participants in the Nurses' Health Study and Health Professionals Follow-up Study from 1986 to 2006. We calculated a 25-hydroxyvitamin D (25(OH) D) score from known predictors of vitamin D status for each individual and then examined the predicted 25(OH) D levels in relation to pancreatic cancer risk. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models adjusted for age, sex, race, height, smoking, and diabetes. We then further adjusted for body mass index (BMI) and physical activity in a sensitivity analysis. RESULTS: During 20 years of follow-up, we identified 575 incident pancreatic cancer cases. Higher 25(OH) D score was associated with a significant reduction in pancreatic cancer risk; compared with the lowest quintile, participants in the highest quintile of 25(OH) D score had an adjusted RR of 0.65 (95% CI = 0.50-0.86; P(trend) = 0.001). Results were similar when we further adjusted for BMI and physical activity. CONCLUSIONS: Higher 25(OH) D score was associated with a lower risk of pancreatic cancer in these two prospective cohort studies. British Journal of Cancer (2010) 102, 1422-1427. doi:10.1038/sj.bjc.6605658 www.bjcancer.com Published online 13 April 2010 (C) 2010 Cancer Research UK
引用
收藏
页码:1422 / 1427
页数:6
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