A triple umpolung sequence for the preparation of highly substituted indanes.

被引：7

作者：

Harrowven, DC ^{[1
]}

Browne, R ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

TETRAHEDRON | 1996年 / 52卷 / 47期

关键词：

D O I：

10.1016/0040-4020(96)00907-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The paper describes a new method for the diastereoselective construction of highly substituted indanes. The key step involves a triple umpolung sequence in which a 2-lithio-2-vinyl-1,3-dithiane is first united with an aryl halide to form a ketenedithioacetal. Transmetallation of the aryl halide with an alkyllithium reagent then generates an alkyl halide and a 2-indanyl-2-lithio-1,3-dithiane. Finally, these combine to complete the sequence. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：14951 / 14960

页数：10

共 32 条

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