Solid phase glycosidation of oligonucleotides

被引：26

作者：

Adinolfi, M ^{[1
]}

Barone, G ^{[1
]}

De Napoli, L ^{[1
]}

Guariniello, L ^{[1
]}

Iadonisi, A ^{[1
]}

Piccialli, G ^{[1
]}

机构：

[1] Univ Naples, Dept Organ & Biol Chem, I-80134 Naples, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 13期

关键词：

solid-phase synthesis; nucleosides; oligonucleotides; glycosidation;

D O I：

10.1016/S0040-4039(99)00228-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CPG-bound nucleosides (deoxyguanosine excepted) can be stereoselectively glycosylated in high yield at their 5'-hydroxyl by a "disarmed" trichloroacetimidate donor in the presence of stoichiometric amounts of TMSOTf (5 eq.) and in short reaction times. These results allowed the solid-phase synthesis of an oligonucleotide functionalized at both ends with sugar residues. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2607 / 2610

页数：4

共 25 条

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