Imaging mass spectrometry and direct analysis of globotriaosylceramide and galabiosylceramide in tissue

被引：5

作者：

Roy, S

Touboul, D

Brunelle, A

Germain, DP

Laprévote, O

Chaminade, P

机构：

[1] Univ Paris 11, Grp Chim Analyt Sud Paris, EA 3343, Fac Pharm, F-92296 Chatenay Malabry, France

[2] CNRS, ICSN, Lab Spectrometrie Masse, F-91198 Gif Sur Yvette, France

[3] Hop Europeen Georges Pompidou, Unite Fonct Genet Clin, F-75015 Paris, France

来源：

M S-MEDECINE SCIENCES | 2005年 / 21卷

关键词：

D O I：

10.1051/medsci/20052111s55

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In Fabry disease, accumulation of globotrianosylceramide and galabiosylceramide are observed by coloration methods associated to optic or electron microscopy. But a new technology, imaging mass spectrometry, may be applied to the analysis of these metabolites in tissue of hemizygous patients with Fabry disease. Advantages and disavantadges of this technic are discussed.

引用

页码：55 / 56

页数：2

共 5 条

[1] Biological tissue imaging with time-of-flight secondary ion mass spectrometry and cluster ion sources [J].