Oxygen-Generating Biomaterials: A New, Viable Paradigm for Tissue Engineering?

被引：225

作者：

Gholipourmalekabadi, Mazaher ^{[1
,2
]}

Zhao, Susan ^{[3
]}

Harrison, Benjamin S. ^{[3
]}

Mozafari, Masoud ^{[4
]}

Seifalian, Alexander M. ^{[5
,6
]}

机构：

[1] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran, Iran

[2] Iran Univ Med Sci, Dept Tissue Engn & Regenerat Med, Fac Adv Technol Med, Tehran, Iran

[3] Wake Forest Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC USA

[4] MERC, Bioengn Res Grp, Nanotechnol & Adv Mat Dept, Tehran, Iran

[5] UCL, Sch Med, Ctr Nanotechnol & Regenerat Med, London, England

[6] NanoRegMed Ltd, London, England

来源：

TRENDS IN BIOTECHNOLOGY | 2016年 / 34卷 / 12期

关键词：

HYPOXIC ENVIRONMENT; CELL-SURVIVAL; SCAFFOLDS; PERFLUOROCARBONS; REGENERATION; RELEASE; CONSTRUCTS; TRANSPORT; HYDROGELS; SYSTEMS;

D O I：

10.1016/j.tibtech.2016.05.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

There have been many attempts to provide sufficient nutrients, especially oxygen, to engineered large tissues to overcome the effects of hypoxia or poor vascularization. Delivering sufficient oxygen to the transplanted cells is one of the most critical issues that affects cell survival and correct maturation of engineered tissues. An emerging approach is using 3D scaffolds made from oxygen-generating biomaterials to tackle transport limitations deep within the engineered tissues. This class of biomaterials has opened a new window for overcoming the challenges associated with ischemia occurring within large tissue constructs. This review critically assesses oxygen-generating reagents, the main approaches for developing oxygen-generating biomaterials, and their potential as 3D scaffolds for regenerative medicine in a clinical setting.

引用

页码：1010 / 1021

页数：12

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