A fully synthetic vaccine consisting of a tumor-associated glycopeptide antigen and a T-Cell epitope for the induction of a highly specific humoral immune response

被引：109

作者：

Dziadek, S

Hobel, A

Schmitt, E

Kunz, H

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Immunol, D-55101 Mainz, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 46期

关键词：

antigens; antitumor agents; glycopeptides; synthetic vaccines; T-cell epitope;

D O I：

10.1002/anie.200501594

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) On target: With the fully synthetic vaccine 1 consisting of a tumor-associated sialyl-Tn glycopeptide antigen from the epithelial mucin MUC1 and a T-cell epitope from ovalbumin, a strong, highly specific immune response (IgG) directed against the glycopeptide antigen was induced in a mouse thereby realizing the most important requirement for the development of synthetic vaccines for the initiation of the body's own immune defense against tumors. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7630 / 7635

页数：6

共 43 条

[21] Synthesis of glycopeptides containing carbohydrate and peptide recognition motifs [J].