Impact of localized radiotherapy on blood immune cells counts and function in humans

被引：94

作者：

Belka, C

Ottinger, H

Kreuzfelder, E

Weinmann, M

Lindemann, M

Lepple-Wienhues, A

Budach, W

Grosse-Wilde, H

Bamberg, M

机构：

[1] Univ Tubingen, Dept Radiat Oncol, D-72076 Tubingen, Germany

[2] Univ Essen Gesamthsch, Dept Immunol, D-45122 Essen, Germany

[3] Univ Tubingen, Dept Physiol, D-72076 Tubingen, Germany

来源：

RADIOTHERAPY AND ONCOLOGY | 1999年 / 50卷 / 02期

关键词：

radiotherapy; seminoma testis; immune function; lymphocyte subsets; lymphocyte function;

D O I：

10.1016/S0167-8140(98)00130-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune cells subsets were prospectively analyzed after localized radiotherapy (LRT). LRT reduced the levels of all lymphocyte subsets, with B-cells and naive T-cells being most sensitive. Lymphocyte function was suppressed, but still within the normal range. Rapid recovery of cytotoxic T-cells/natural killer cells after LRT and the functional suppression within normal levels explains the low incidence of infections after LRT. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：199 / 204

页数：6