In vivo veritas:: The search for TB drug targets goes live

被引：65

作者：

McKinney, JD ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Infect Biol, New York, NY 10021 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 12期

关键词：

D O I：

10.1038/82142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The term microbial persistence' describes a phenomenon whereby microorganisms which are drug-susceptible when tested outside the body are nevertheless capable of surviving within the body despite intensive therapy with the appropriate antimicrobial drug. In clinical practice this phenomenon obviously has to do with the post-treatment 'carrier state' and with post-treatment relapse. In short, it is this phenomenon which is responsible for our inability to eradicate an infection from a person or a community by the use of drugs.

引用

页码：1330 / 1333

页数：4

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