Metabolomics

被引:213
作者
Idle, Jeffrey R. [1 ]
Gonzalez, Frank J.
机构
[1] Charles Univ Prague, Fac Med 1, Inst Pharmacol, Prague 12800 2, Czech Republic
[2] Natl Canc Inst, Lab Metab, Canc Res Ctr, NIH, Bethesda, MD 20894 USA
关键词
D O I
10.1016/j.cmet.2007.10.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Metabolomics is the systematic identification and quantitation of all metabolites in a given organism or biological sample. The enhanced resolution provided by nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), along with powerful chemometric software, allows the simultaneous determination and comparison of thousands of chemical entities, which has lead to an expansion of small molecule biochemistry studies in bacteria, plants, and mammals. Continued development of these analytical platforms will accelerate the widespread use of metabolomics and allow further integration of small molecules into systems biology. Here, recent studies using metabolomics in xenobiotic metabolism and genetically modified mice are highlighted.
引用
收藏
页码:348 / 351
页数:4
相关论文
共 15 条
[1]  
Brindle JT, 2002, NAT MED, V8, P1439, DOI 10.1038/nm802
[2]   Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone) [J].
Chen, Chi ;
Meng, Linghua ;
Ma, Xiaochao ;
Krausz, Kristopher W. ;
Pommier, Yves ;
Idle, Jeffrey R. ;
Gonzalez, Frank J. .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2006, 318 (03) :1330-1342
[3]   Pharmaco-metabonomic phenotyping and personalized drug treatment [J].
Clayton, TA ;
Lindon, JC ;
Cloarec, O ;
Antti, H ;
Charuel, C ;
Hanton, G ;
Provost, JP ;
Le Net, JL ;
Baker, D ;
Walley, RJ ;
Everett, JR ;
Nicholson, JK .
NATURE, 2006, 440 (7087) :1073-1077
[4]   Perspective - Applications of metabolomics in agriculture [J].
Dixon, Richard A. ;
Gang, David R. ;
Charlton, Adrian J. ;
Fiehn, Oliver ;
Kuiper, Harry A. ;
Reynolds, Tracey L. ;
Tjeerdema, Ronald S. ;
Jeffery, Elizabeth H. ;
German, J. Bruce ;
Ridley, William P. ;
Seiber, James N. .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (24) :8984-8994
[5]   Metabolomics - the link between genotypes and phenotypes [J].
Fiehn, O .
PLANT MOLECULAR BIOLOGY, 2002, 48 (1-2) :155-171
[6]   Metagenomic analysis of the human distal gut microbiome [J].
Gill, Steven R. ;
Pop, Mihai ;
DeBoy, Robert T. ;
Eckburg, Paul B. ;
Turnbaugh, Peter J. ;
Samuel, Buck S. ;
Gordon, Jeffrey I. ;
Relman, David A. ;
Fraser-Liggett, Claire M. ;
Nelson, Karen E. .
SCIENCE, 2006, 312 (5778) :1355-1359
[7]   Towards a holistic, yet gene-centered analysis of gene expression profiles: A case study of human lung cancers [J].
Guo, Yuchun ;
Eichler, Gabriel S. ;
Feng, Ying ;
Ingber, Donald E. ;
Huang, Sui .
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2006,
[8]   Microbial ecology - Human gut microbes associated with obesity [J].
Ley, Ruth E. ;
Turnbaugh, Peter J. ;
Klein, Samuel ;
Gordon, Jeffrey I. .
NATURE, 2006, 444 (7122) :1022-1023
[9]   Physiological genomics of Escherichia coli protein families [J].
Liang, P ;
Labedan, B ;
Riley, M .
PHYSIOLOGICAL GENOMICS, 2002, 9 (01) :15-26
[10]   Metabonomics in pharmaceutical R & D [J].
Lindon, John C. ;
Holmes, Elaine ;
Nicholson, Jeremy K. .
FEBS JOURNAL, 2007, 274 (05) :1140-1151