Antiallergic activity of Andrographolides isolated from Andrographis paniculata (Burm F) Wall

被引：26

作者：

Gupta, PP ^{[1
]}

Tandon, JS ^{[1
]}

Patnaik, GK ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Pharmacol, Lucknow 226001, Uttar Pradesh, India

来源：

PHARMACEUTICAL BIOLOGY | 1998年 / 36卷 / 01期

关键词：

Andrographis paniculata; andrographolide; antiallergic activity; neoandrographolide; mast cell degranulation;

D O I：

10.1076/phbi.36.1.72.4620

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Andrographis paniculata is widely used in traditional remedies in India in a number of clinical conditions including allergic manifestations. Two diterpenes, andrographolide and neoandrographolide, isolated from the plant, were evaluated for their antiallergic activity. These were tested for anti-PCA (Passive cutaneous anaphylaxis) and mast cell stabilizing activities in rats. Significant anti-PCA activity was observed. The compounds also possessed mast cell stabilizing activity against compound 48/80 and in sensitized mast cells, against egg albumin induced degranulation. The activities were found to be comparable to disodium cromoglycate.

引用

页码：72 / 74

页数：3

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