A diastereoselective tandem metalloenamine alkylation/aza-annulation of beta-tetralones expedites the synthesis of benzoquinolinones

被引：5

作者：

Audia, JE ^{[1
]}

Droste, JJ ^{[1
]}

Dunigan, JM ^{[1
]}

Bowers, J ^{[1
]}

Heath, PC ^{[1
]}

Holme, DW ^{[1
]}

Eifert, JH ^{[1
]}

Kay, HA ^{[1
]}

Miller, RD ^{[1
]}

Olivares, JM ^{[1
]}

Rainey, TF ^{[1
]}

Weigel, LO ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY RES LABS,CHEM PROC RES & DEV,INDIANAPOLIS,IN 46285

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 24期

关键词：

D O I：

10.1016/0040-4039(96)00724-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In one operation, metalloenamines derived from R-phenylethylamine (PEA) and a beta-tetralone were treated with an electrophile followed by acrylic anhydride. The unpurified lactams were reduced to give 10b-angular benzoquinolinones (BQs). (C) 1996 Elsevier Science Ltd

引用

页码：4121 / 4124

页数：4

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