Role of chance in familial aggregation of colorectal cancer

被引：7

作者：

Katballe, N ^{[1
]}

Bentzen, SM

Christensen, M

Wikman, FP

Orntoft, T

Laurberg, S

机构：

[1] Aarhus Univ Hosp, Aarhus Kommune Hosp, Dept Surg L, Surg Res Unit 900, DK-8000 Aarhus, Denmark

[2] Mt Vernon Hosp, Gray Lab Canc Res Trust, Northwood HA6 2JR, Middx, England

[3] Aarhus Univ Hosp, Skejby Sygehus, Dept Clin Biochem, DK-8000 Aarhus, Denmark

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 08期

关键词：

HNPCC; hereditary non-polyposis colorectal cancer; Amsterdam criteria; incidence; coincidence;

D O I：

10.1054/bjoc.2000.1717

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A prospective population-based study recorded family trees of 77 colorectal cancer patients younger than 50 years of age. Using mathematical modeling of population age-incidence data, we estimate that 1 (95% confidence limits 0 and 3) of these families is expected to meet the Amsterdam criteria I for HNPCC due to chance clustering of colorectal cancer. (C) 2001 Cancer Research Campaign.

引用

页码：1084 / 1086

页数：3

共 9 条

[1] DETECTION OF NEW MUTATIONS IN 6 OUT OF 10 SWISS HNPCC FAMILIES BY GENOMIC SEQUENCING OF THE HMSH2 AND HMLH1 GENES [J].

BUERSTEDDE, JM ;

ALDAY, P ;

TORHORST, J ;

WEBER, W ;

MULLER, H ;

SCOTT, R .

JOURNAL OF MEDICAL GENETICS, 1995, 32 (11) :909-912

[2] Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer [J].

Moslein, G ;

Tester, DJ ;

Lindor, NM ;

Honchel, R ;

Cunningham, JM ;

French, AJ ;

Halling, KC ;

Schwab, M ;

Goretzki, P ;

Thibodeau, SN .

HUMAN MOLECULAR GENETICS, 1996, 5 (09) :1245-1252

[3] Suspected hereditary nonpolyposis colorectal cancer - International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis [J].

Park, JG ;

Vasen, HFA ;

Park, KJ ;

Peltomaki, P ;

de Leon, MP ;

Rodriguez-Bigas, MA ;

Lubinski, J ;

Beck, NE ;

Bisgaard, ML ;

Miyaki, M ;

Wijnen, JT ;

Baba, S ;

Lynch, HT .

DISEASES OF THE COLON & RECTUM, 1999, 42 (06) :710-715

[4]

STORM HH, 1994, CANC INCIDENCE DENMA

[5] THE INTERNATIONAL-COLLABORATIVE-GROUP-ON-HEREDITARY-NON-POLYPOSIS-COLORECTAL-CANCER (ICG-HNPCC) [J].

VASEN, HFA ;

MECKLIN, JP ;

KHAN, PM ;

LYNCH, HT .

DISEASES OF THE COLON & RECTUM, 1991, 34 (05) :424-425

[6]

Viel A, 1997, GENE CHROMOSOME CANC, V18, P8, DOI 10.1002/(SICI)1098-2264(199701)18:1<8::AID-GCC2>3.0.CO

[7]

2-7

[8] Clinical findings with implications for genetic testing in families with clustering of colorectal cancer [J].

Wijnen, JT ;

Vasen, HFA ;

Khan, PM ;

Zwinderman, AH ;

van der Klift, H ;

Mulder, A ;

Tops, C ;

Moller, P ;

Fodde, R ;

Menko, F ;

Taal, B ;

Nagengast, F ;

Brunner, H ;

Kleibeuker, J ;

Sijmons, R ;

Griffioen, G ;

Bröcker-Vriends, A ;

Bakker, E ;

van Leeuwen-Cornelisse, I ;

Meijers-Heijboer, A ;

Lindhout, D ;

Breuning, M ;

Post, J ;

Schaap, C ;

Apold, J ;

Heimdal, K ;

Bertario, L ;

Bisgaard, ML ;

Goetz, P .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (08) :511-518

[9] Efficient mutation detection in mismatch repair genes using a combination of single-strand conformational polymorphism and heteroduplex analysis at a controlled temperature [J].

Wikman, FP ;

Katballe, N ;

Christensen, M ;

Laurberg, S ;

Orntoft, TF .

GENETIC TESTING, 2000, 4 (01) :15-21

← 1 →