Statins Personalized

被引：49

作者：

Superko, H. Robert ^{[1
,2
,3
]}

Momary, Kathryn M. ^{[2
]}

Li, Yonghong ^{[1
]}

机构：

[1] Celera Corp, Alameda, CA 94502 USA

[2] Mercer Univ, Coll Pharm & Hlth Sci, Atlanta, GA 30341 USA

[3] St Josephs Hosp Atlanta, Atlanta, GA 30342 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2012年 / 96卷 / 01期

关键词：

Genetic; Cholesterol; Statin; Coronary heart disease; Polymorphism; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-E GENOTYPES; GENOME-WIDE ASSOCIATION; KINESIN-LIKE PROTEIN-6; COENZYME-A REDUCTASE; LIPID-LEVELS; CHOLESTEROL RESPONSE; TRP719ARG POLYMORPHISM; MYOCARDIAL-INFARCTION;

D O I：

10.1016/j.mcna.2011.11.004

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor medications, commonly referred to as statins, are among the most widely prescribed medications. Variation in individual response to statins concerning low-density lipoprotein cholesterol reduction, clinical event benefit, and side effects has been observed. Some of this variability is attributed to demographic and environmental issues, chief of which is compliance. A large portion of the individual response to statin therapy is attributed to single nucleotide polymorphisms that have recently been elucidated, several of which seem to have clinical utility.

引用

页码：123 / +

页数：18

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