Palladium-catalyzed reactions for fine chemical synthesis. Part 24: A new palladium catalyst system for the cyanation of aryl chlorides

被引：143

作者：

Sundermeier, M

Zapf, A

Beller, M

Sans, J

机构：

[1] Univ Rostock EV IfOK, Inst Organ Katalyseforsch, D-18055 Rostock, Germany

[2] Degussa AG, Werk Trostberg, D-83303 Trostberg, Germany

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(01)01390-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The influence of reaction conditions and additives on the palladium-catalyzed cyanation of aryl chlorides with potassium cyanide has been investigated. Successful cyanation of aryl chlorides is observed in the presence of palladium catalysts using potassium cyanide. It is shown that the combination of a 1,5-bis(diphenylphosphino)pentane ligand and the addition of N,N,N',N'-tetramethylethylenediamine (TMEDA) as a co-catalyst are the key factors in obtaining the corresponding aryl nitriles with improved catalyst productivities and selectivities. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6707 / 6710

页数：4

共 44 条

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