Free radical-induced double lesions in DNA

被引：117

作者：

Box, HC ^{[1
]}

Dawidzik, JB ^{[1
]}

Budzinski, EE ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Mol & Cellular Biophys, Buffalo, NY 14263 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2001年 / 31卷 / 07期

关键词：

free radical-induced DNA damage; radiation-induced DNA damage; double lesions; tandem lesions; vicinal lesions; DNA damage; Fenton chemistry; reactive oxygen species (ROS); DNA repair; free radicals;

D O I：

10.1016/S0891-5849(01)00653-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review surveys the work that has been done on free radical-induced DNA double lesions, Double lesions consist of two modifications of the DNA in close proximity. Double lesions can be generated by a single free radical-initiating event and the mechanism of formation often involves the participation of guanine. The identification of double lesions in oligomer and polymer DNA is reviewed and possible mechanisms of formation are outlined. The potential biological significance of double lesions is discussed. Double lesions induced by UV light are outside the scope of this review. (C) 2001 Elsevier Science Inc.

引用

页码：856 / 868

页数：13

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