The architecture of the tau haplotype block in different ethnicities

被引：12

作者：

Fung, HC

Evans, J

Evans, W

Duckworth, J

Pittman, A

de Silva, R

Myers, A

Hardy, J

机构：

[1] Natl Inst Aging, Neurogenet Lab, Natl Inst Hlth, Bethesda, MD 20892 USA

[2] UCL, Reta Lila Weston Inst Neurol Studies, London W1T 4JF, England

[3] Chang Gung Univ, Chang Gung Mem Hosp, Dept Neurol 2, Taipei 10591, Taiwan

[4] Chang Gung Univ, Coll Med, Taipei 10591, Taiwan

来源：

NEUROSCIENCE LETTERS | 2005年 / 377卷 / 02期

关键词：

tau; MAPT gene; populations genetics; FTDP-17; progressive supranuclear palsy; linkage disequilibrium;

D O I：

10.1016/j.neulet.2004.11.072

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have assessed the pattern of the extended haplotype block over the tau gene which covers a region of similar to 2 Mb in different ethnicities. This analysis shows that the pattern of linkage disequilibrium over the tau region is shared by different ethnic groups indicating that haplotype structure in human is ancient. We discuss this observation in terms of the establishment of the haplotype structure and the possible impact of the tau haplotype on neurodegeneration in humans. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：81 / 84

页数：4

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