Synthesis and cytotoxicity of silylalkylthio-substituted N-heterocycles and their hydroselenites

被引：7

作者：

Arsenyan, P ^{[1
]}

Rubina, K ^{[1
]}

Shestakova, I ^{[1
]}

Abele, E ^{[1
]}

Abele, R ^{[1
]}

Domracheva, I ^{[1
]}

Nesterova, A ^{[1
]}

Popelis, J ^{[1
]}

Lukevics, E ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, LV-1006 Riga, Latvia

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2003年 / 17卷 / 11期

关键词：

antitumor activity; cytotoxicity; morphology; selenium; silicon;

D O I：

10.1002/aoc.530

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

New hydroselenites of the different silylalkylthio-substituted N-heterocycles have been prepared by the reaction of selenium dioxide with N-heterocycles in an aqueous medium. Their structure was confirmed by H-1, C-13, and Se-77 NMR data. Most of these silylalkylthio-substituted N-heterocycles and their hydroselenites have an expressed cytotoxic activity on the MG-22A (mouse hepatoma), HT-1080 (human fibrosarcoma), B16 (mouse melanoma), and Neuro 2A (mouse neuroblastoma) cell lines. Some of the hydroselenites exhibit free-radical protection simultaneously with a high cytotoxic effect. The substances studied were also active in vivo against sarcoma S-180. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：825 / 830

页数：6

共 17 条

[1]

Abele E., 1999, Chem. Heterocycl. Compd, V35, P1052, DOI [10.1007/BF02251796, DOI 10.1007/BF02251796]

[2] Organoammonium hydroselenites: antitumor action through radical balance regulation [J].

Arsenyan, P ;

Shestakova, I ;

Rubina, K ;

Domracheva, I ;

Nesterova, A ;

Vosele, K ;

Pudova, O ;

Lukevics, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 465 (03) :229-235

[3]

ASIAK J, 2002, TERATOGEN CARCINOGEN, V22, P73

[4]

Bauer G, 2000, HANDB EXP PHARM, V142, P275

[5] NITRIC-OXIDE PRODUCTION BY TUMOR TARGETS IN RESPONSE TO TNF - PARADOXICAL CORRELATION WITH SUSCEPTIBILITY TO TNF-MEDIATED CYTOTOXICITY WITHOUT DIRECT INVOLVEMENT IN THE CYTOTOXIC MECHANISM [J].

FAST, DJ ;

LYNCH, RC ;

LEU, RW .

JOURNAL OF LEUKOCYTE BIOLOGY, 1992, 52 (03) :255-261

[6] Molecular mechanisms of cancer prevention by selenium compounds [J].

Fleming, J ;

Ghose, A ;

Harrison, PR .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2001, 40 (01) :42-49

[7]

Flohé L, 2000, IUBMB LIFE, V49, P411

[8]

Freshney P. J., 1994, CULTURE ANIMAL CELLS, P296

[9] Amino-acid hydroselenites: synthesis and cytotoxicity [J].

Lukevics, E ;

Arsenyan, P ;

Rubina, K ;

Shestakova, I ;

Domracheva, I ;

Nesterova, A ;

Popelis, J ;

Pudova, O .

APPLIED ORGANOMETALLIC CHEMISTRY, 2002, 16 (04) :235-238

[10] Synthesis, structure and cytotoxicity of organoammonium selenites [J].

Lukevics, E ;

Arsenyan, P ;

Shestakova, I ;

Domracheva, I ;

Kanepe, I ;

Belyakov, S ;

Popelis, J ;

Pudova, O .

APPLIED ORGANOMETALLIC CHEMISTRY, 2002, 16 (04) :228-234

← 1 2 →