How Sunlight Causes Melanoma

被引：89

作者：

Garibyan, Lilit ^{[1
,2
]}

Fisher, David E. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp Boston, Cutaneous Biol Res Ctr,Dept Dermatol, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp Boston, Melanoma Program, Boston, MA 02114 USA

来源：

CURRENT ONCOLOGY REPORTS | 2010年 / 12卷 / 05期

关键词：

Ultraviolet; Melanoma; Tanning; Carcinogenesis; Immunosuppression; CYCLOBUTANE PYRIMIDINE DIMERS; PLATELET-ACTIVATING-FACTOR; SKIN-CANCER; MALIGNANT-MELANOMA; ULTRAVIOLET-RADIATION; MOLECULAR-MECHANISMS; CUTANEOUS MELANOMA; BRAF MUTATIONS; SUN EXPOSURE; UV;

D O I：

10.1007/s11912-010-0119-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of melanoma has continued to rise dramatically over the past few decades, especially in young females. Due to the deadly nature of this disease, melanoma has become an important public health problem. It is generally accepted that ultraviolet light radiation (UVR) from sunlight is a major risk factor for melanoma skin cancer development. However, the mechanistic details of how sunlight via UVR causes melanoma are still being elucidated. Currently, it is thought that carcinogenic, inflammatory, and immunosuppressive properties of UVR all contribute to initiation, progression, and metastasis of primary melanoma. We review current findings on how sunlight-generated UVR generates DNA damage, inflammation, and immune suppression, thus leading to melanoma.

引用

页码：319 / 326

页数：8

共 58 条

[1] The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: A role for UVA in human skin carcinogenesis [J].