Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis

被引：401

作者：

Feller, Martin

Huwiler, Karin

Stephan, Roger

Altpeter, Ekkehardt

Shang, Aijing

Furrer, Hansjakob

Pfyffer, Gaby E.

Jemmi, Thomas

Baumgartner, Andreas

Egger, Matthias

机构：

[1] Univ Bern, Inst Social & Prevent Med, CH-3012 Bern, Switzerland

[2] Univ Zurich, Inst Food Safety & Hyg, Zurich, Switzerland

[3] Swiss Fed Off Publ Hlth, Bern, Switzerland

[4] Univ Bern, Inst Infect Dis, Bern, Switzerland

[5] Cantonal Hosp Lucerne, Dept Med Microbiol, Luzern, Switzerland

[6] Swiss Fed Vet Off, Bern, Switzerland

[7] Univ Bristol, Dept Social Med, Bristol, Avon, England

来源：

LANCET INFECTIOUS DISEASES | 2007年 / 7卷 / 09期

关键词：

D O I：

10.1016/S1473-3099(07)70211-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This systematic review assesses the evidence for an association between Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn's disease. We analysed 28 case-control studies comparing MAP in patients with Crohn's disease with individuals free of inflammatory bowel disease (IBD) or patients with ulcerative colitis. Compared with individuals free of IBD, the pooled odds ratio (OR) from studies using PCR in tissue samples was 7.01 (95% CI 3.95-12.4) and was 1.72 (1.02-2.90) in studies using ELISA in serum. ORs were similar for comparisons with ulcerative colitis patients (PCR, 4.13 [1.57-10.9]; ELISA, 1.88 [1.26-2.81]). The association of MAP with Crohn's disease seems to be specific, but its role in the aetiology of Crohn's disease remains to be defined.

引用

页码：607 / 613

页数：7

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