Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study

被引：295

作者：

Kakinuma, Ryutaro ^{[1
,2
,3
]}

Noguchi, Masayuki ^{[4
]}

Ashizawa, Kazuto ^{[5
]}

Kuriyama, Keiko ^{[6
]}

Maeshima, Akiko Miyagi ^{[7
]}

Koizumi, Naoya ^{[8
]}

Kondo, Tetsuro ^{[9
]}

Matsuguma, Haruhisa ^{[10
]}

Nitta, Norihisa ^{[11
]}

Ohmatsu, Hironobu ^{[12
]}

Okami, Jiro ^{[13
]}

Suehisa, Hiroshi ^{[14
,15
]}

Yamaji, Taiki ^{[16
,17
]}

Kodama, Ken ^{[13
,18
]}

Mori, Kiyoshi ^{[19
,20
]}

Yamada, Kouzo ^{[9
]}

Matsuno, Yoshihiro ^{[21
]}

Murayama, Sadayuki ^{[22
]}

Murata, Kiyoshi ^{[11
]}

机构：

[1] Natl Canc Ctr, Canc Screening Div, Res Ctr Canc Prevent & Screening, Tokyo, Japan

[2] Natl Canc Ctr, Canc Screening Ctr, Tokyo, Japan

[3] Tokyo Gen Hosp, Dept Pulmonol, Tokyo, Japan

[4] Univ Tsukuba, Dept Pathol, Fac Med, Tsukuba, Ibaraki, Japan

[5] Nagasaki Univ, Grad Sch Biomed Sci, Dept Clin Oncol, Nagasaki, Japan

[6] Osaka Natl Hosp, Dept Radiol, Osaka, Japan

[7] Natl Canc Ctr, Dept Pathol, Tokyo, Japan

[8] Niigata Canc Ctr, Dept Radiol, Niigata, Japan

[9] Kanagawa Canc Ctr, Dept Thorac Oncol, Yokohama, Kanagawa, Japan

[10] Tochigi Canc Ctr, Dept Thorac Surg, Utsunomiya, Tochigi, Japan

[11] Shiga Univ Med Sci, Dept Radiol, Otsu, Shiga, Japan

[12] Natl Canc Ctr Hosp East, Dept Thorac Oncol, Kashiwa, Chiba, Japan

[13] Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gen Thorac Surg, Osaka, Japan

[14] Shikoku Canc Ctr, Dept Thorac Surg, Matsuyama, Ehime, Japan

[15] Iwakuni Clin Ctr, Dept Thorac Surg, Iwakuni, Japan

[16] Natl Canc Ctr, Epidemiol & Prevent Div, Res Ctr Canc Prevent & Screening, Tokyo, Japan

[17] Natl Canc Ctr, Div Epidemiol, Ctr Publ Hlth Sci, Tokyo, Japan

[18] Yao Municipal Hosp, Dept Thorac Surg, Yao, Japan

[19] Tochigi Canc Ctr, Dept Thorac Oncol, Utsunomiya, Tochigi, Japan

[20] Tsuboi Canc Ctr Hosp, Dept Pulmonol, Koriyama, Fukushima, Japan

[21] Hokkaido Univ Hosp, Dept Surg Pathol, Sapporo, Hokkaido, Japan

[22] Univ Ryukyus, Fac Med, Dept Radiol, Okinawa, Japan

来源：

JOURNAL OF THORACIC ONCOLOGY | 2016年 / 11卷 / 07期

关键词：

Subsolid nodule; Ground -glass nodule; Natural history; Computed tomography; Lung adenocarcinoma; GROUND-GLASS OPACITY; THIN-SECTION CT; HIGH-RESOLUTION CT; DOSE SPIRAL CT; TERM-FOLLOW-UP; LUNG-CANCER; BASE-LINE; INVASIVE COMPONENT; SOLID COMPONENT; GROWTH;

D O I：

10.1016/j.jtho.2016.04.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Introduction: The purpose of this study was to evaluate the natural course of the progression of pulmonary subsolid nodules (SSNs). Materials and Methods: Eight facilities participated in this study. A total of 795 patients with 1229 SSNs were assessed for the frequency of invasive adenocarcinomas. SSNs were classified into three categories: pure ground-glass nodules (PGGNs), heterogeneous GGNs (HGGNs) (solid component detected only in lung windows), and part-solid nodules. Results: The mean prospective follow-up period was 4.3 2.5 years. SSNs were classified at baseline as follows: 1046 PGGNs, 81 HGGNs, and 102 part-solid nodules. Among the 1046 PGGNs, 13 (1.2%) developed into HGGNs and 56 (5.4%) developed into part-solid nodules. Among the 81 HGGNs, 16 (19.8%) developed into part-solid nodules. Thus, the SSNs at the final follow-up were classified as follows: 977 PGGNs, 78 HGGNs, and 174 part-solid nodules. Of the 977 PGGNs, 35 were resected (nine minimally invasive adenocarcinomas [MIAs], 21 adenocarcinomas in situ [AIS], and five atypical adenomatous hyperplasias). Of the 78 HGGNs, seven were resected (five MIAs and two AIS). Of the 174 part-solid nodules, 49 were resected (12 invasive adenocarcinomas, 26 MIAs, 10 AIS, and one adenomatous hyperplasia). For the PGGNs, the mean period until their development into part-solid nodules was 3.8 +/- 2.0 years, whereas the mean period for the HGGNs was 2.1 +/- 2.3 years (p = 0.0004). Conclusion: This study revealed the frequencies and periods of development from PGGNs and HGGNs into part solid nodules. Invasive adenocarcinomas were diagnosed only among the part-solid nodules, corresponding to 1% of all 1229 SSNs. (C) 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

引用

页码：1012 / 1028

页数：17

共 48 条

[1]

Adenocarcinomas with Predominant Ground-Glass Opacity: Correlation of Morphology and Molecular Biomarkers [J].

Aoki, Takatoshi ;

Hanamiya, Mai ;

Uramoto, Hidetaka ;

Hisaoka, Masanori ;

Yamashita, Yoshiko ;

Korogi, Yukunori .

RADIOLOGY, 2012, 264 (02) :590-596

[2]

Radiologic Implications of the 2011 Classification of Adenocarcinoma of the Lung [J].

Austin, John H. M. ;

Garg, Kavita ;

Aberle, Denise ;

Yankelevitz, David ;

Kuriyama, Keiko ;

Lee, Hyun-Ju ;

Brambilla, Elisabeth ;

Travis, William D. .

RADIOLOGY, 2013, 266 (01) :62-71

[3]

The British Thoracic Society guidelines on the investigation and management of pulmonary nodules [J].

Baldwin, David R. ;

Callister, Matthew E. J. .

THORAX, 2015, 70 (08) :794-798

[4]

Natural History of Pure Ground-Glass Opacity Lung Nodules Detected by Low-Dose CT Scan [J].

Chang, Boksoon ;

Hwang, Jung Hye ;

Choi, Yoon-Ho ;

Chung, Man Pyo ;

Kim, Hojoong ;

Kwon, O. Jung ;

Lee, Ho Yun ;

Lee, Kyung Soo ;

Shim, Young Mog ;

Han, Joungho ;

Um, Sang-Won .

CHEST, 2013, 143 (01) :172-178

[5]

Transient subsolid nodules in patients with extrapulmonary malignancies: their frequency and differential features [J].

Choi, Won Seok ;

Park, Chang Min ;

Song, Yong Sub ;

Lee, Sang Min ;

Wi, Jae Yeon ;

Goo, Jin Mo .

ACTA RADIOLOGICA, 2015, 56 (04) :428-437

[6]

Pulmonary Ground-Glass Nodules: Increase in Mass as an Early Indicator of Growth [J].

de Hoop, Bartjan ;

Gietema, Hester ;

van de Vorst, Saskia ;

Murphy, Keelin ;

van Klaveren, Rob J. ;

Prokop, Mathias .

RADIOLOGY, 2010, 255 (01) :199-206

[7]

Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer? Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J].

Gould, Michael K. ;

Donington, Jessica ;

Lynch, William R. ;

Mazzone, Peter J. ;

Midthun, David E. ;

Naidich, David P. ;

Wiener, Renda Soylemez .

CHEST, 2013, 143 (05) :E93-E120

[8]

Fleischner Society:: Glossary of terms tor thoracic imaging [J].

Hansell, David M. ;

Bankier, Alexander A. ;

MacMahon, Heber ;

McLoud, Theresa C. ;

Mueller, Nestor L. ;

Remy, Jacques .

RADIOLOGY, 2008, 246 (03) :697-722

[9]

Growth rate of small lung cancers detected on mass CT screening [J].

Hasegawa, M ;

Sone, S ;

Takashima, S ;

Li, F ;

Yang, ZG ;

Maruyama, Y ;

Watanabe, T .

BRITISH JOURNAL OF RADIOLOGY, 2000, 73 (876) :1252-1259

[10]

CT screening for lung cancer: Frequency and significance of part-solid and nonsolid nodules [J].

Henschke, CI ;

Yankelevitz, DF ;

Mirtcheva, R ;

McGuinness, G ;

McCauley, D ;

Miettinen, OS .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2002, 178 (05) :1053-1057

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