Lipid and polymeric carrier-mediated nucleic acid delivery

被引：117

作者：

Zhu, Lin ^{[1
]}

Mahato, Ram I. ^{[1
]}

机构：

[1] Univ Tennessee, Hlth Sci Ctr, Dept Pharmaceut Sci, Memphis, TN 38103 USA

来源：

EXPERT OPINION ON DRUG DELIVERY | 2010年 / 7卷 / 10期

关键词：

lipid; liposomes; non-viral gene delivery; nucleic acid; oligonucleotides; polymer; siRNA; POLY(ETHYLENE GLYCOL)-SIRNA CONJUGATE; POLYELECTROLYTE COMPLEX MICELLES; CATIONIC PLGA NANOSPHERES; NONVIRAL GENE DELIVERY; LOW-MOLECULAR-WEIGHT; IN-VIVO; PLASMID DNA; TRANSFECTION EFFICIENCY; MAMMALIAN-CELLS; VEGF SIRNA;

D O I：

10.1517/17425247.2010.513969

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Importance of the field: Nucleic acids such as plasmid DNA, antisense oligonucleotide, and RNA interference (RNAi) molecules, have a great potential to be used as therapeutics for the treatment of various genetic and acquired diseases. To design a successful nucleic acid delivery system, the pharmacological effect of nucleic acids, the physiological condition of the subjects or sites, and the physicochemical properties of nucleic acid and carriers have to be thoroughly examined. Areas covered in this review: The commonly used lipids, polymers and corresponding delivery systems are reviewed in terms of their characteristics, applications, advantages and limitations. What the reader will gain: This article aims to provide an overview of biological barriers and strategies to overcome these barriers by properly designing effective synthetic carriers for nucleic acid delivery. Take home message: A thorough understanding of biological barriers and the structure activity relationship of lipid and polymeric carriers is the key for effective nucleic acid therapy.

引用

页码：1209 / 1226

页数：18

共 136 条

[1] A novel tetraester construct that reduces cationic lipid-associated cytotoxicity. Implications for the onset of cytotoxicity [J].

Aberle, AM ;

Tablin, F ;

Zhu, J ;

Walker, NJ ;

Gruenert, DC ;

Nantz, MH .

BIOCHEMISTRY, 1998, 37 (18) :6533-6540

[2] Stabilized plasmid-lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression [J].

Ambegia, E ;

Ansell, S ;

Cullis, P ;

Heyes, J ;

Palmer, L ;

MacLachlan, I .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2005, 1669 (02) :155-163

[3] RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection [J].

Barkerand, Gregory A. ;

Diamond, Scott L. .

MOLECULAR THERAPY, 2008, 16 (09) :1602-1608

[4] EFFICIENT GENE-TRANSFER INTO MAMMALIAN PRIMARY ENDOCRINE-CELLS WITH LIPOPOLYAMINE-COATED DNA [J].

BEHR, JP ;

DEMENEIX, B ;

LOEFFLER, JP ;

MUTUL, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :6982-6986

[5] Sticky overhangs enhance siRNA-mediated gene silencing [J].

Bolcato-Bellemin, Anne-Laure ;

Bonnet, Marie-Elise ;

Creusatt, Gaeelle ;

Erbacher, Patrick ;

Behr, Jean-Paul .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (41) :16050-16055

[6] Formation of plasmid-based transfection complexes with an acid-labile cationic lipid:: characterization of in vitro and in vivo gene transfer [J].

Boomer, JA ;

Thompson, DH ;

Sullivan, SM .

PHARMACEUTICAL RESEARCH, 2002, 19 (09) :1292-1301

[7] Chitosans for gene delivery [J].

Borchard, G .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 52 (02) :145-150

[8] A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].

BOUSSIF, O ;

LEZOUALCH, F ;

ZANTA, MA ;

MERGNY, MD ;

SCHERMAN, D ;

DEMENEIX, B ;

BEHR, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301

[9] A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity [J].

Bramsen, Jesper B. ;

Laursen, Maria B. ;

Nielsen, Anne F. ;

Hansen, Thomas B. ;

Bus, Claus ;

Langkjaer, Niels ;

Babu, B. Ravindra ;

Hojland, Torben ;

Abramov, Mikhail ;

Van Aerschot, Arthur ;

Odadzic, Dalibor ;

Smicius, Romualdas ;

Haas, Jens ;

Andree, Cordula ;

Barman, Jharna ;

Wenska, Malgorzata ;

Srivastava, Puneet ;

Zhou, Chuanzheng ;

Honcharenko, Dmytro ;

Hess, Simone ;

Mueller, Elke ;

Bobkov, Georgii V. ;

Mikhailov, Sergey N. ;

Fava, Eugenio ;

Meyer, Thomas F. ;

Chattopadhyaya, Jyoti ;

Zerial, Marino ;

Engels, Joachim W. ;

Herdewijn, Piet ;

Wengel, Jesper ;

Kjems, Jorgen .

NUCLEIC ACIDS RESEARCH, 2009, 37 (09) :2867-2881

[10] Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles [J].

Braun, CS ;

Vetro, JA ;

Tomalia, DA ;

Koe, GS ;

Koe, JG ;

Middaugh, CR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2005, 94 (02) :423-436

← 1 2 3 4 5 6 7 8 9 10 →